Valdecoxib mucoadhesive matrix prepared with sodium alginate and coated inside eudragit s 100 as an antiinflammatory drug was reported by zhang et al. Pdf several approaches have been immerged to prolong the residence time of the. Research paper preparation and characterization of. Gastroretentive mucoadhesive tablet research articles. In vitro release of metoclopramide from mucoadhesive microspheres formulations, al a2 a3 a, microspheres was slow and extended and it depended on the processing parameters and polymer to drug ratio. Mucoadhesive microspheres which are of 110 00mm in diameter and. Mucoadhesive microspheres have advantages like efficient. Vara lakshmi faculty of pharmaceutical sciences, rajiv gandhi college of pharmacy, rajahmundry, east godavari, andhra pradesh, india. Microspheres of eudragit rsrl100, containing cinnarizine, were prepared by emulsification solvent evaporation technique employing 32 full factorial design. Amoxicillin mucoadhesive microspheres containing carbopol934p as mucoadhesive polymer and ethyl. In general, we know that small intestine is mostly the site for drug absorption but in some cases the drug needs to be targeted to some other sites for absorption due to various factors like any disease condition, degradation related situations, for sustained release of drugs etc. Solid biodegradable microspheres incorporating a drug.
Microspheres are small spherical particles, with diameters in the micrometer range typically 1. When compared to conventional sitagliptin administration, use of a nanoparticle delivery system demonstrated greater benefits for use in oral delivery applications. Different methods of formulation and evaluation of mucoadhesivemicrosphere harshad parmar, sunil bakliwal. Keywords serratiopeptidase, cholic acid, chitosan mucoadhesive microspheres 1. Advances in orally targeted drug delivery to colon belali. Mucoadhesive microspheres as carriers in drug delivery. The aim of the present investigation was to evaluate the potential use of mucoadhesive microspheres for gastroretentive delivery of acyclovir. In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal for either systemic or local effects. Colonspecific drug delivery systems cdds are desirable for the treatment of a range of local diseases such as ulcerative colitis, crohns disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. This study focuses on evaluation of the chitosan methylcellulose interpenetrating polymer network csmc ipn microspheres intended for mucoadhesive gastroretentive application and the optimization of formulation of cinnarizineloaded csmc ipns using response surface methodology rsm. Quality by design based fabrication of iron oxide induced. It is expected that mucoadhesive microspheres containing antih. Phase separation is then accomplished by changing the solution conditions by the salt addition, onsolvent addition, addition of the incompatible polymer or change in ph.
Formulation and invitro evaluation of mucoadhesive buccal films of glibenclamide p. Microspheres composed of hydroxypropyl methylcellulose h, chitosan cs, carbopol 934p cp and various combinations of these mucoadhesive polymers, and maltodextrin m, colloidal silicon dioxide a, and propylene glycol p as filler and shaper, were prepared by spraydrying technique. The term microsphere is defined as a spherical particle with size varying from 50nm to 2m, containing a core substance. Hpmc and eudragit s 100 were received as a gift samples from glukem pharmaceuticals p ltd, india. The purpose of this research was to prepare spraydried mucoadhesive microspheres for nasal delivery.
Microspheres received much attention not only for prolonged release, but also for targeting of drugs. Formulation and invitro evaluation of mucoadhesive floating. Content definition history material used criteria for selection of method methods of preparation applications references 2sagar savale. Mucoadhesivetopenetrating controllable peptosomesin. The purpose of present research work was to develop mucoadhesive microspheres for nasal delivery with the aim to avoid. Formulation and evaluation of mucoadhesive microspheres of. Mucoadhesive systems in oral drug delivery promise the advantage of a prolonged gastric or small intestinal residence time, an intimate contact of the delivery system with the absorption membrane and the basis for interactions of multifunctional polymers with the mucosa such as permeation enhancement or enzyme inhibition. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat noncolonic conditions. Mucoadhesive microspheres constitute an important part of these particulate drug delivery. It has been confirmed that these mucoadhesive microspheres have the ability to adhere to the stomach wall in rats and thereby remain in the gastrointestinal tract for an extended period. Preparation and evaluation of mucoadhesive microsphere of fluoxetine hcl html full text. Results of preliminary trials indicate that volume of crosslinking agent, time for.
Microsphere brachytherapy using the beta emission of 90 y is used in the treatment of hepatic malignancies. Curcumin was a gift sample from krish enteprizes, mumbai, india. The study demonstrates the preparation of mucoadhesive microspheres of metoclopramide using chitosan as a polymer. Microspheres are sometimes referred to as spherical microparticles. Mucoadhesive microspheres for gastroretentive delivery of. Formulation and evaluation of mucoadhesive glipizide. The objective of the present study is related to the preparation and evaluation of mucoadhesive microspheres of simvastatin by using different polymers like sodium alginate, hpmc k100m, sodium cmc, ethyl cellulose, methyl cellulose. S annamacharya college of pharmacy, rajampet516126, andhra pradesh state, india email. Pdf carrier technology provides an interesting as well as an intelligent. Naproxen sodium mucoadhesive polymer made of sodium alginate and eudragit s100 for the treatment of colitis was prepared by chawla et al.
Mucoadhesive drug delivery system, mucoadhesion, polymer introduction the basic rationale of controlled drug delivery system is to optimize the biopharmaceutical. Mucoadhesive drug delivery systems are used to enhance drug absorption in a sitespecific manner. Mucoadhesive microsphere carrier systems were made from the biodegradable polymers in sustained drug delivery. Particle size was calculated by using equation, xg 10 x ni x log xi n, where, xg is geometric mean diameter, ni is number of particle in range, xi is the midpoint of range and n is the total number of particles.
Mucoadhesive microspheres have advantages like efficient absorption and improved bioavailability of the drugs due to a high surface to volume ratio, a much more intimate contact with the mucus. Microspheres are made from polymeric, waxy or protective materials that is biodegradable synthetic polymers and modified natural products. Most treatments take place in interventional radiology departments with the support of. The mucoadhesive microspheres of piroxicam were prepared by nonaqueous emulsification solvent evaporation method. As a result, drug is localized on the targeted site. Morphology by sem of optimized formulation f1 in vitro drug release the microspheres bearing hpmc k4m and atenolol were spherical in shape and in the range of desired particle size. Clsm method for the dynamic observation of ph change. Microspheres as a promising mucoadhesive drug delivery system. The most desirable and convenient method of drug administration is the oral route due to the ease of administration and patient compliance.
Mucoadhesive nanoparticles were formulated using sitagliptin and were effective for about 12 hours in the gastrointestinal tract. In the present study, we explored the potential of rivastigmine loaded solid lipid nanoparticle sln, as a new formulation in improving the bioavailability of antialzheimer drug rivastigmine which otherwise reported with poor bioavailability. Jagadeesh singh the mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic circulation and avoiding the first pass metabolism. Hollow microspheres are used as additives to lower the density of a material. The purpose of research work was to develop and optimize mucoadhesive microspheres of levocetirizine for nasal delivery with the aim to enhance the residence time and improve therapeutic efficacy and at the same time increase the local absorption of drug and reducing systemic side effects and also to develop unique delivery system for patients suffering from allergy and rhinitis. Preparation and evaluation of mucoadhesive microspheres of. Other features associated with the development of control led drug delivery systems using bioadhesive molecules include a. Mucoadhesive topenetrating controllable peptosomesin microspheres coloaded with antimir31 oligonucleotide and curcumin for targeted colorectal cancer therapy.
Microspheres are manufactured in both solid and hollow form. Microspheres methods for preparation of microspheres. Evolution of an existing drug molecule from a conventional form to a novel delivery system can significantly improve its performance in terms of patient compliance, safety and efficacy. Mucoadhesive microspheres which are of 110 00mm in diameter and consisting e ither. The microspheres swelled when in contact with moisture and released the drug, fig. Formulation and evaluation of nasal mucoadhesive microspheres of. The rationale of developing mucoadhesive microspheres are that the formulation will be confined on a biological surface for localized drug delivery and the drug will be released close to the site of action with a consequent enhancement of bioavailability. Formulation and evaluation of stomachspecific amoxicillinloaded.
Microspheres methods for preparation of microspheres 1. The aim of present work was to prepare mucoadhesive microspheres containing clarithromycin, an antih. Department of pharmaceutics 1, department of pharmaceutical chemistry 2, rajarambapu college of pharmacy, kasegaon 415404. Mucoadhesive delivery systems are being explored for the localization of the active agents to a particular site. The micrioemulsion based method was adopted for preparation of sln. The surface charge can be determined by relating measured. Microspheres constitute an important part of these pdf floating systems for oral controlled release drug delivery floating systems for oral controlled release drug delivery. A 32 full factorial experiment was designed to study the effect of independent. All types of microspheres that have been used as nasal drug delivery systems are waterinsoluble but absorb water into the spheres matrix, resulting in swelling of the spheres and the formation of a gel. Design and fabrication of gastroretentive bilayer floating tablet of. Jcprc5 525 formulation and optimization of mucoadhesive simvastatin microspheres from natural and synthetic polymers rashmi gupta, rajesh asija, shailendra bhatt and sangeeta asija department of pharmaceutics, maharishi arvind institute of pharmacy, mansarovar, jaipur, rajasthan, india. The rationale of developing mucoadhesive microsphere drug delivery system lies. Microspheres, in general, have the potential to be used for targeted and controlled release drug delivery.
Mucoadhesive microspheres have advantages like efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio, a much more intimate contact with the mucus. Mucoadhesive microspheres bioadhesion controlled drug delivery the oral route of drug administration constitutes the most convenient and preferred means of drug delivery to systemic circulation of body but has short gastrointestinal tract. Formulation and characterization of rivastigmine loaded. Formulation and invitro evaluation of mucoadhesive floating microspheres of repaglinide using solvent evaporation method k. Nanoparticle an overview of preparation and carbon. Mucoadhesive microspheres were prepared by calcium induced ionotropic gelation method. Development and evaluation of floating microspheres of. Formulation into a polymer matrix is a potential method to improve their stability. If acidsensitive drugs or cells are administered orally, there is often a reduction in efficacy associated with gastric passage. Zhao r, du s, liu y, lv c, song y, chen x, zhang b, li d, gao s, cui w, plikus mv, hou x, wu k, liu z, liu z, cong y, li y, yu z. Formulation and in vitro evaluation of acyclovir mucoadhesive.
The present study involves preparation and characterization of mucoadhesive microspheres with famotidine as model drug for prolongation of gastric residence time. In general microspheres are solid or hollow and do not have a fluid inside, as opposed to microcapsules. Get the kumari latest news, news in nagercoil, kanyakumari news, nagercoil news, latest news in nagercoil, local nagercoil news, nagercoil latest news, kanyakumari latest news, kumari news. The microspheres were prepared by the wo emulsification solvent evaporation method using mucoadhesive polymers sod. The building materials in the microspheres have been starch, dextran, albumin.
An appropriately designed novel drug delivery system can be a major advance for solving the problems related. This is an open access article which permits unrestricted. Asian journal of pharmaceutical and clinical research. In the form of a novel drug delivery system an existing drug molecule can get a new life. A central composite design ccd for two factors at three levels each was employed to systematically. Chitosan, thiolated chitosan, carbopol 71g and methocel k15m were used as mucoadhesive polymers. Mucoadhesive systems in oral drug delivery sciencedirect. Microspheres containing pioglitazone hydrochloride were prepared by the ionotropic external gelation method, using sodium alginate with four mucoadhesive polymers namely sodium carboxy methyl cellulose, hydroxy propyl methyl cellulose, carbopol 934 p and cellulose acetate phthalate as coat materials. Colon targeted drug delivery is a relatively new concept for the absorption of drugs as it offers near. Glipizide microspheres containing chitosan were prepared by simple emulsification phase separation technique using glutaraldehyde as a crosslinking agent. In future microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, genetic materials. The study was aimed to enhance the mucoadhesive potential of eudragit rs 100 and rl 100 using iron oxide. The purpose of this research was to formulate and systematically evaluate in vitro and in vivo performances of mucoadhesive microspheres of glipizide.
Nanoparticle an overview of preparation and free download as pdf file. Formulation and in vitro evaluation of acyclovir mucoadhesive microspheres for. The concept of targeted drug delivery is designed for attempting to concentrate the drug in the tissues of interest while reducing the relative concentration of the medication in the remaining tissues. In addition, some related terms are beads are used alternatively.
Formulation and evaluation of mucoadhesive buccal films of. Crosslinked chitosan based stomach specific mucoadhesive. However, the terms microspheres and microencapsulationare used synonymously. Microspheres are, in strict sense, spherical empty particles. Gluteraldehyde cross linked mucoadhesive microspheres. Please cite this article in press as syed tazib rahaman et al. Related publications journal of pharmaceutical sciences the aim of the journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. Introduction microspheres can be defined as solid, spherical, free flowing, smooth surface particles ranging in size from 1 to 4m. Formulations package the 90 y in small glass microspheres 20 to 60 m in diameter, which are injected into the hepatic artery. Belgian polymer group bpg and the swiss chemical society scs are affiliated with polymers and their members receive a discount on the article processing charges. Preparation of floating microspheres floating microspheres were prepared by. Mucoadhesive microspheres containing amoxicillin for. Formulation and evaluation of mucoadhesive glipizide microspheres.
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